Study: Appendix cancer rates increasing in millennials

The rising incidence of appendix cancer among millennials has emerged as a concerning trend in oncological research. A recent study published in the *Annals of Internal Medicine* indicates that rates of appendiceal cancer have quadrupled among individuals born between 1981 and 1989, while cases have tripled for those born between 1976 and 1984 . This alarming increase necessitates heightened awareness regarding the symptoms associated with this malignancy, including abdominal pain, bloating, changes in bowel habits, and loss of appetite . The findings underscore the urgency for both healthcare providers and patients to remain vigilant about these symptoms to facilitate early diagnosis and intervention.

An analysis of a National Cancer Institute database found that compared with older generations, rates of appendix cancer have tripled among Gen X and quadrupled among millennials, according to the report, published Monday in the Annals of Internal Medicine.

“There is a disproportionate burden of appendix cancer among young individuals,” said the study’s lead author, Andreana Holowatyj, an assistant professor of hematology and oncology at the Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center.

Holowatyj’s earlier research was “the first to show that 1 in every 3 appendix cancers is diagnosed among adults younger than age 50,” she said in a phone interview. “That’s compared to 1 in every 8 colorectal cancers diagnosed among adults younger than age 50.”

Dr. Holowatyj explained that about 95 percent of appendix cancers are only found after someone has surgery for appendicitis. When the appendix is removed, it is checked under a microscope, and that's when the cancer is usually discovered. Because of this delay, the cancer is often found at a late stage and has a lower chance of a good outcome.

A National Cancer Institute data analysis reveals a growing trend of gastrointestinal cancers in younger demographics, with millennials experiencing a significant increase in appendiceal cancer compared to older generations.This increase, though statistically significant, warrants further investigation to determine the underlying causes. Researchers are exploring potential links to dietary changes, environmental factors, and alterations in gut microbiome composition. While the overall incidence of gastrointestinal cancers remains higher in older adults, the rising rates among younger individuals underscore the importance of early screening and awareness campaigns tailored to this demographic. The NCI study emphasizes the need for continued research to identify specific risk factors and develop targeted prevention strategies to mitigate the impact of these cancers across all age groups.

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Sara H

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