G-quadruplex-forming DNA molecules enhance enzymatic activity of myoglobin ...Middle East

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G-quadruplex-forming DNA molecules enhance enzymatic activity of myoglobin
source : ( Middle East ) () 6
A collaboration led by Distinguished Professor Dr. Kazunori Ikebukuro from Tokyo University of Agriculture and Technology (TUAT), Japan, discovered that G-quadruplex (G4)-forming DNA binds myoglobin through a parallel-type G4 structure. Through the G4 binding, the enzymatic activity of myoglobin increases over 300-fold compared to that of myoglobin alone (Figure). This finding indicates that DNA may work as a carrier of genetic information in living organisms and act as a regulator of unknown biological phenomena.

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