San Francisco (6-10) rides a three-game losing streak into a matchup with (-) on Sunday, January 5, 2025 at State Farm Stadium. The Cardinals are listed as favorites in this one, with the spread sitting at 4.5 points. The over/under is set at 43 in the outing.
Facing the Detroit Lions in their last game, the 49ers lost 40-34.
Against the Lions, Brock Purdy completed 27 of 35 attempts for 377 yards, with three touchdowns and two interceptions, for the Niners.
Last time around, the Cardinals fell to the Los Angeles Rams, with 13-9 being the final score.
49ers vs Cardinals betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:47 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
Spread Favorite: Arizona (-4.5) Moneyline: Arizona (-223), San Francisco (+183) Total: 43 points49ers betting insights
San Francisco is 2-5 overall, with just one win against the spread, on the road. The 49ers are 5-11-0 against the spread this season. On the road, San Francisco is winless ATS (0-2) as 4.5-point underdogs or more. The 49ers are winless against the spread when they are 4.5-point underdogs or more (0-2). San Francisco has hit the over in five of seven road games this season. 49ers games have finished with a final combined score above the over/under 10 times this season.49ers leaders
Isaac Guerendo: 82 CAR / 415 YDS / 27.7 YPG / 4 TD / 15 REC / 152 YDS / 10.1 YPG / 0 TD Purdy: 66 CAR / 323 YDS / 21.5 YPG / 5 TD George Kittle: 76 REC / 1,079 YDS / 77.1 YPG / 8 TD Jauan Jennings: 70 REC / 923 YDS / 65.9 YPG / 6 TD Deebo Samuel: 51 REC / 670 YDS / 44.7 YPG / 3 TD49ers vs Cardinals game info
Date: Sunday, January 5, 2025 Time: 4:25 p.m. ET City: Glendale, Arizona Venue: State Farm Stadium TV Channel: FOX Live Stream: Fubo (Watch Cardinals vs 49ers on Fubo) Watch the San Francisco 49ers all season on Fubo!More NFL news
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