Hundreds of weight loss and diabetes jab users have reported problems with their pancreas, with some cases proving fatal, according to new data.
Data from the medicines regulator shows that since the drugs were licensed there have been hundreds of cases of acute and chronic pancreatitis among people taking GLP-1 medicines, the group of drugs that includes Ozempic, Wegovy and Mounjaro.
The cases are not confirmed as being caused by the medicines, but the person who reported them suspected they may be.
Health officials are now launching a new study into potential side effects and are urging users who experience pancreas problems to take part.
Recent estimates suggest that about 1.5 million people in the UK are taking weight loss jabs.
According to figures from the Medicines and Healthcare products Regulatory Agency (MHRA), there have been 181 reported cases of acute and chronic pancreatitis linked to tirzepatide – the active ingredient for Mounjaro. Five people died.
There were 113 cases of acute and chronic pancreatitis linked to semaglutide – the active ingredient for Ozempic and Wegovy, with one reported death.
Another 116 reported reactions of this kind linked to liraglutide, one of which was fatal.
Figures also showed 101 reported similar reactions to exenatide, with three people dying. There were also 52 reported reactions linked to dulaglutide and 11 reported reactions lixisenatide. No fatalities were linked to either drug.
Yellow Card Biobank project, a study launched by the MHRA and Genomics England, will see researchers examine whether cases of pancreatitis linked to GLP-1 drugs may be influenced by peoples genetic makeup.
The MHRA is calling for people who are taking GLP-1 medicine who have been admitted to hospital due to acute pancreatitis to submit a report to its Yellow Card scheme.
When a Yellow Card report is received, the MHRA will contact patients to ask if they would be willing to take part in the study.
Patients will be asked to submit more information and a saliva sample which will be assessed to explore whether some people are at a higher risk of acute pancreatitis when taking these medicines due to their genes.
GLP-1 agonists can lower blood sugar levels in people living with type 2 diabetes and can also be prescribed to support some people with weight loss.
Health officials have suggested that they can help to turn the tide on obesity, but have stressed they are not a silver bullet and do come with side effects.
Most side effects linked to the jabs are gastrointestinal including nausea, constipation and diarrhoea.
And the medical regulator recently warned that Mounjaro may make the oral contraceptive pill less effective in some patients.
Dr Alison Cave, MHRA’s chief safety officer, said: “Evidence shows that almost a third of side effects to medicines could be prevented with the introduction of genetic testing, it is predicted that adverse drug reactions could cost the NHS more than £2.2 billion a year in hospital stays alone.
“Information from the Yellow Card Biobank will help us to better predict those most at risk of adverse reactions – enabling patients across the UK to receive the safest medicine for them, based on their genetic makeup.”
Professor Matt Brown, chief scientific officer of Genomics England, said: “GLP-1 medicines like Ozempic and Wegovy have been making headlines, but like all medicines there can be a risk of serious side effects.
“We believe there is real potential to minimise these with many adverse reactions having a genetic cause.
“This next step in our partnership with the MHRA will generate data and evidence for safer and more effective treatment through more personalised approaches to prescription, supporting a shift towards an increasingly prevention-focused healthcare system.”
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