The actress, who famously starred as the titular character Meredith Grey on the hit medical drama, recently opened up about one "awkward" moment on set that involved her good friend and co-star T.R. Knight.
While making an appearance on the Wednesday, March 19 episode of Alex Cooper's Call Her Daddy podcast, Pompeo, 55, recalled filming a love scene with Knight, 51, who starred as George O'Malley.
"T.R. and I are such good friends, and we had to do a love scene. We were both crying. We cried," she divulged. "The scene was so uncomfortable and awkward. He didn’t want to do that. I didn’t wanna do it, and when we filmed it, it was so bad."
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"The network said there was too much thrusting," Pompeo added. "In your worst nightmare, to have to do it one time, we had to reshoot that shit. We had to reshoot it and do it twice."
"I've never seen it," she said of the scene, which is featured in Season 2 episode 19, titled "What Have I Done to Deserve This?"
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