Manchester United and PAOK presents a critical opportunity for both teams. Manchester United, currently struggling with only three points from their first three matches, aims to secure its inaugural victory in the competition . Conversely, PAOK has fared even worse, managing just one point thus far. This match is particularly significant as it marks Ruud van Nistelrooy's penultimate game before Ruben Amorim assumes managerial duties .
Interim manager Ruud van Nistelrooy takes charge of his penultimate game at the helm, with United looking for their first three points of the new campaign after three disappointing draws in their opening games.
United currently sit 23rd in the league phase table, just within the play-off places, and will need to pick up points in their next matches in order to avoid another two games during a congested winter period in the new year.
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Red Devils to attack with real menace here. 
Gianpaolo Castorina’s side are 2nd in the Greek Super League, only a point behind the leaders, Aris. Former Manchester United attacker Shola Shoretire is in their ranks and could be in line for a start on Thursday. 
Just like United, PAOK have yet to secure a win in the Europa League. However, they have managed to earn a solitary point, which means they sit 30th in the table coming into matchday four. 
However, Van Nistelrooy might approach the situation with an element of caution and continue with Manuel Ugarte and Casemiro alongside each other for the third game running. Bruno Fernandes should start after missing the last Europa League fixture through suspension.
In attack, it seems unlikely that Van Nistelrooy will make any alterations, particularly for a game United need to get three points out of. It means Rasmus Hojlund is likely to be supported by Marcus Rashford and Alejandro Garnacho from the flanks.
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