Sean Newcomb (1-4) struck out three in three scoreless innings in relief of starter Jacob Lopez for the win. Grant Holman pitched a scoreless eighth and Mason Miller tossed a 1-2-3 ninth to end it.
The Athletics took a 1-0 lead off Orioles starter Tomoyuki Sugano in the first inning after Lawrence Butler led off with a base hit before scoring on Soderstrom's two-out single.
Pereda atoned for the errant throw with a go-ahead RBI double in the Athletics' second. Butler drove in a run on a fielder's choice before Wilson singled to make it 4-1.
Lopez allowed four hits in four innings and struck out five before giving way to Newcomb.
The Orioles were coming off a three-game sweep of the Mariners in Seattle.
Key stat
Wilson finished 2 for 4 and has multiple hits in five straight games and seven overall while going 20 for 40 during a nine-game hitting streak. The rookie shortstop raised his batting average to .372 and trails only the Yankees' Aaron Judge, who began the day hitting .390.
Up next
The Orioles head home for six games and hadn't announced a starter for the first of three against the Tigers beginning Tuesday. Detroit will start RHP Sawyer Gipson-Long (0-0, 7.36).
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