The BAFTA nominee has been confirmed to play disability rights activist Judy Heumann, known as "the Mother of the disability rights movement", in an adaptation of her bestselling memoir, which will be adapted, produced, and directed by Oscar winner Siân Heder.
The film will focus around the 28-day sit-in of the San Francisco Federal Building by a group of more than 100 disabled people that Heumann led in 1977.
Madeley, who is a strong advocate for disability representation on screen, expressed her delight at being cast in the role in a statement after it was announced.
"Judy has always been a source of inspiration for me personally and I am so excited to share her story with the world. This is truly the role of a lifetime."
In the 2018 BBC documentary Spina Bifida & Me, she delved into the impact of the condition, her own journey with it, and new developments in the area.
Beyond Madeley, the rest of the cast has not yet been revealed.
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