But now, the actress is turning to the gritty medium of crime thrillers as she takes the lead in Long Bright River, a new series that's just landed on Channel 4.
Seyfried takes on the role of Mickey, a police officer who patrols a Philadelphia neighbourhood that's been hit hard by the opioid crisis. But her personal ties to a murder case threaten to upend her life, with the series following Mickey as she struggles to make sense of the truth.
The full cast list for Long Bright River is as follows. Scroll on to find out more about the characters, plus where you may recognise the cast from.
Amanda Seyfried as Mickey FitzpatrickNicholas Pinnock as Truman DawesAshleigh Cummings as Kacey FitzpatrickCallum Vinson as Thomas FitzpatrickJohn Doman as GeeMatthew Del Negro as Simon CleareDash Mihok as Eddie LaffertyBritne Oldford as Dr Aura WilliamsHarriet Sansom Harris as Mrs MahonPatch Darragh as Sergeant AhearnJoe Daru as Davis DanjaratPerry Mattfeld as PaulaAmanda Seyfried as Mickey Fitzpatrick
Where have I seen Amanda Seyfried? Seyfried is known for her roles in Mean Girls, the Mamma Mia! films and Veronica Mars. She has also starred in The Dropout, The Crowded Room, Les Misérables and Dear John.
Nicholas Pinnock as Truman Dawes
Where have I seen Nicholas Pinnock? The British actor is known for his roles in For Life, Django, Marcella and Counterpart. He has also starred in This Town, Fortitude, Top Boy and Criminal: UK.
Ashleigh Cummings as Kacey Fitzpatrick
Where have I seen Ashleigh Cummings? The Australian actress is known for her roles in series such as Citadel, Miss Fisher's Murder Mysteries, Puberty Blues and NOS4A2.
Callum Vinson as Thomas Fitzpatrick
Where have I seen Callum Vinson? Vinson has previously starred in the Chucky TV series, FBI: International and Prime Video's Dead Ringers.
John Doman as Gee
Where have I seen John Doman? Doman has starred in numerous productions over the years, including standout roles in Borgia, The Wire, ER and Gotham. He has also starred in The Affair, The Big Cigar and Eric.
Matthew Del Negro as Simon Cleare
Where have I seen Matthew Del Negro? Del Negro is known for his roles in Scandal, The West Wing, The Sopranos and City on a Hill. He has also starred in Mayor of Kingstown, Teen Wolf and Mistresses.
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