Caltrans' website says traffic is being turned around three miles east of Gold Run and at the Nevada state line due to spin-outs.
A winter storm warning is in effect through the night and into Thursday. A winter storm watch is also in effect as a second storm is expected to bring heavy snow to the Sierra again Thursday night.
It's unknown when any of the highways will reopen.
Highway 50 has chain controls in place from Placerville to Meyers.
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