Watch live: Plane crash in Philadelphia, 6 people on board; multiple houses on fire, massive emergency response ...Middle East

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The plane, a Learjet 55, had just departed Northeast Philadelphia Airport bound for Springfield, Missouri, when it went down, according to a statement from the Federal Aviation Administration. 

Newly confirmed Transportation Secretary Sean Duffy said there were six people aboard the plane. According to a statement from Jet Rescue Air Ambulance, the six included four crew members, a pediatric patient, and the patient's escort. 

Police said multiple people on the ground were hurt. According to a Temple University Hospital spokesperson, six people were taken to Temple's Jeanes Campus. Three were treated and released and three remained hospitalized in fair condition, the hospital said.

"So sad to see the plane go down in Philadelphia, Pennsylvania," President Trump said in a social media post. "More innocent souls lost. Our people are totally engaged. First Responders are already being given credit for doing a great job. More to follow. God Bless you all."  

In a news conference Friday night, Philadelphia Mayor Cherelle Parker said she had "no reports on the number of fatalities."

Parker said several homes and vehicles were impacted. Residents were cautioned to stay out of the area. 

Parker said federal and state agencies were either en route to Philadelphia or already on the ground.   

Multiple rowhomes on fire, plane parts hit cars

Police sources told CBS News Philadelphia's Chief Investigative Reporter Joe Holden that parts of the plane hit cars in the area. Some businesses near the Roosevelt Mall were also on fire, sources said. 

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Ring camera video from one home in the area captured the moment the jet crashed.

CBS Philadelphia

Philadelphia OEM said drivers should expect the extended closure of Cottman Avenue between Roosevelt Boulevard and Bustleton Avenue and the outer southbound lanes of Roosevelt Boulevard as they continue to respond to the scene.

Neighbors felt their homes shake

"I saw blinking lights coming from the sky. And I just saw them going down," said a 10-year-old boy on his way home from hockey practice. "It was really scary."

"I just was driving and I saw a lot of police activity and then people texting me. I was close here and that there was a plane crash," Weis said. "And my daughter who GPS'd me, freaked, called me and was making sure that I was OK." 

CBS Philadelphia

"I don't want to say it was like an earthquake, but it was like someone knocking on the door really hard," he said.

Red Cross Philadelphia and the School District of Philadelphia have opened a shelter for anyone needing housing or support at Samuel Fels High School located at 5500 Langdon St.  

"The mayor preaches about 'one Philly,'" Pennsylvania Gov. Josh Shapiro said in a second news briefing alongside Parker later Friday. "She talks about a unified approach to governing every day. What you're seeing here is a unified response to an awful aviation disaster. For as awful as that aviation disaster was, tonight we also saw the best of Philly. We saw neighbor helping neighbor. We saw Pennsylvanians looking out for one another."  

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