The crash happened around 5:45 a.m. on Mitchell Road, just south of Tenaya Drive.
The woman driving the Ford died at the scene, officers said. Two passengers in the Ford, a 34-year-old woman from Hughson and a 67-year-old man from Waterford, were taken to a nearby hospital with major injuries, the CHP said.
It's unknown if DUI was a factor in the crash.
The roadway was closed until about 8:15 a.m.
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