The crash, involving a Cessna 550 plane, occurred near Sculpin Street and Santo Road, close to the 15 Freeway. Police said the southbound Santo Road at Aero Drive is closed.
"Our city will be supporting these families who are impacted here," said San Diego Mayor Todd Gloria. "They are part of the military community that makes up our city."
"I can't quite put words to describe what this scene looks like, but with the jet fuel going down the street and everything all on fire all at once, it was pretty horrific to see," said San Diego Police Chief Scott Wahl.
Preliminary information from the Federal Aviation Administration said the plane crashed near the Montgomery-Gibbs Executive Airport around 3:45 a.m. When crews from the San Diego Fire Department arrived on the scene, they quickly worked to extinguish fires at homes and cars.
The fire department said no one was transported from the scene to local hospitals.
The FAA and the National Transportation Safety Board will investigate the cause of the crash.
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