United take a 3-0 lead over Athletic Bilbao into their clash at Old Trafford.
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Should United and Spurs set up a meeting for silverware, it would be the first all-Premier League final since Chelsea defeated Arsenal in Baku in 2019.
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The game will kick off at 8pm UK time.
Where is the Europa League final in 2025?
The 53,331-seater stadium has hosted the showpiece game once before, in 2011/12, when Chelsea won their first European trophy by beating Bayern Munich on penalties at their own ground.
Watch the Europa League final 2025 on TV and live stream
The Europa League final 2025 will be live on TNT Sports.
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