The 45th London Marathon, sponsored by IT firm Tata Consultancy Services (TCS), will see competitors coming from across the globe and all walks of life to participate.
Alongside will be comedians Romesh Ranganathan and Joel Dommett, presenter Kelly Brook, West End star and X Factor winner Alexandra Burke, McFly band member Harry Judd and the Body Coach Joe Wicks.
And there will be tens of thousands of runners hoping to complete the world-famous course and raise some funds for their favoured charity.
Highlights of the course include the Houses of Parliament (Photo: Henry Nicholls/ AFP/Getty)For the elite wheelchair athletes, the start is 8.50am followed by elite women at 9.05am and elite men at 9.35am.
The London Marathon starts at Greenwich Park and ends near Buckingham Palace (Photo: TCS London Marathon)
What is the London Marathon route, and which roads will be closed?
The 26.2-mile course wends its way from Greenwich Park in south-east London to The Mall outside Buckingham Palace.
There will be road closures in several areas across the city and south of the river.
Road closures on this part of the route will be from 8am to 8.30pm.
Limehouse Montgomery Street Water Street Bank Street Charter Street Trafalgar Way Marsh Wall Westferry Road Eastferry Road Poplar High StreetRoad closures on this part of the route will be from 7am to 4pm.
Romney Road Creek Road King William Walk Trafalgar RoadRoads will close at 7am on this part of the route. Roads to the south of Westcombe Park are anticipated to reopen by 2.30pm, while roads to the north of Westcombe Park are anticipated to reopen by 3pm.
Woolwich Road Charlton Way Shooters Hill Road St Johns Park Old Dover Road Vanbrugh Park Charlton Road Charlton Park Road Charlton Park Lane Runners will wend their way through Greenwich, Canary Wharf, the City and Westminster to get to the finish line (Photo: TCS London Marathon)Road closures on the part of the route will be from 8am to 4pm.
Lower Road Surrey Quays Road Quebec Way Salter Road Brunel Road Jamaica RoadRoad closures on this part of the route will be from 7.30am to 10pm.
Pall Mall East Trafalgar Square Cockspur Street Strand westbound (entire road) Strand eastbound (between Trafalgar Square and Bedford Street) Charing Cross Road (between Strand and William IV Street) Duncannon StreetRoad closures on this part of the route will be from 8am to 8.30pm.
Narrow Street Commercial Road The Highway Tower BridgeTower Bridge is a midway point for runners and a popular spot for spectators (Photo: Alishia Abodunde/Getty)
The London Marathon is as much a spectator event as it is a sporting one, with the streets of the Capital lined with well-wishers each year to cheer on the competitors.
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Read MoreBusy areas tend to be around the Cutty Sark in Greenwich, Tower Bridge, Canary Wharf, Tower Hill and Westminster.
There are also five accessible viewing areas along the course: Cutty Sark, Canary Wharf, Rainbow Row, Tower Hill, and Victoria Embankment.
Gabby Logan is presenting live, with commentary from Andrew Cotter, Steve Cram, Paula Radcliffe and Baroness Tanni Grey-Thompson.
Abby Cook, JJ Chalmers, Jeanette Kwakye, and Sarah Mulkerrins will report from the 26.2-mile route.
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