There is currently no effective treatment for paralysis caused by serious spinal cord injuries, which affect more than 150,000 patients in Japan alone, with 5,000 new cases each year.
They can then be prompted to mature into different kinds of cells, with the Keio researchers using iPS-derived cells of the neural stem.
No serious adverse event was observed for all four cases after a year of monitoring, the university said.
Public broadcaster NHK reported that one of the two was an elderly man who suffered the injury in an accident.
“We were able to achieve results in the world’s first spinal cord treatment with iPS,“ Hideyuki Okano, a Keio professor who heads the research, said, according to NHK.
The university received government approval for their initial study in 2019 and they carried out the first operation in 2022.
The number of cells implanted was determined after safety experiments in animals.
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