Sabonis suffered a cut over his left eye and blood trickled down his face after the Kings' big man was hit in the face by the back of Luke Kennard's head. Sabonis returned but left for good in the third quarter after rolling his right ankle.
The Kings are 21-15 since interim coach Doug Christie replaced Mike Brown in December.
Desmond Bane scored a season-high 44 points for the Grizzlies. Zach Edey had 12 points and eight rebounds.
Grizzlies: Memphis put up a good fight even without their best player, an encouraging start to their longest road trip of the season.
Key moment
The Kings responded very well each time Sabonis was taken to the locker room. They expanded their lead both times without him, which enabled Sacramento to not to have to rush Sabonis back.
Up next
The Grizzlies continue their longest road trip of the season against the Trail Blazers on Wednesday. The Kings host the Cavaliers on Wednesday.
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