Francis has been suffering from a respiratory infection for more than a week and was admitted to Rome's Gemelli Hospital on February 14.
Bilateral pneumonia is a serious infection that can inflame and scar both lungs, and makes breathing more difficult.
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“Nevertheless, Pope Francis remains in good spirits,“ the Vatican statement added.
A Vatican official, who declined to be named because of the sensitivity of the issue, said earlier in the day that the pontiff had not been put on a ventilator and was breathing on his own.
The pope had been due to lead several events over the weekend for the 2025 Catholic Holy Year, which runs through to next January.
Doctors say a polymicrobial infection occurs when two or more micro-organisms are involved, and can be caused by bacteria, viruses, or fungi.
The pope has been plagued by ill health in recent years, including regular bouts of flu, sciatica nerve pain and an abdominal hernia that required surgery in 2023.
The Vatican statement on Tuesday said he was grateful for all the support he has received in recent days. “With a thankful heart, (he) asks for continued prayers on his behalf,“ it added.
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