Kelyan Bokassa died after he was attacked in broad daylight last week in the Woolwich area of southeast London, the latest in a string of shocking knife deaths involving teenagers.
Police said the two suspects being questioned were aged 15 and 16.
She said that during his troubled life he had been identified by authorities as at risk of gang involvement from the age of six.
His killing came a day after an 18-year-old boy was seriously injured in a stabbing a few miles (kilometres) away.
Around 27,000 young people aged 10-17 were in 2017 identified as being members of a street gang, according to figures published in a recent Ministry of Justice report.
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