Goff threw a go-ahead touchdown pass to Amon-Ra St. Brown in the final minute of the third quarter following the first of Kerby Joseph's two second-half interceptions against Brock Purdy in a rematch of last season's NFC title game won by San Francisco.
The stakes for this game were miniscule compared to the last meeting between the teams when a berth in the Super Bowl was on the line last January. San Francisco was eliminated from playoff contention last week and Detroit plays Minnesota in the regular-season finale next week with the winner earning the NFC North title and top seed in the NFC playoffs, and the loser being relegated to a wild card.
Jahymr Gibbs put the game away with a 30-yard touchdown run with less than three minutes left following Purdy's second interception, giving him 117 yards on the night.
He threw a short pass to St. Brown, who immediately pitched the ball to Jameson Williams, who streaked down the sideline for the final 41 yards and his second TD of the first half.
Purdy threw a 5-yard pop pass for a TD on San Francisco's opening drive of the second half before Detroit's defense finally managed a stop when Joseph intercepted an overthrown pass by Purdy.
Moody missed a 58-yard field goal that could have tied the game early in the fourth quarter for his ninth missed field goal of the season. Moody also missed an extra point after Joshua Dobbs scored on a TD run in the final minute.
49ers: Visit Arizona on Sunday.
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