Yu Huaying, 60, separated at least 17 children from their parents and sold them to other families during the 1990s.
But state media reported Thursday that a court in southwestern Guizhou province had rejected her appeal and upheld capital punishment.
“The case will now be submitted to the Supreme People’s Court for review... and then will enter the implementation stage,“ CCTV said.
In recent years, child kidnappings have featured more prominently in popular culture, and state media gave Yu’s case extensive coverage.
Now in her 30s, Yang Niuhua documented her search for her birth family on social media, but found her biological parents had already died.
During her appeal, the court discovered enough additional evidence to convict her of trafficking a further six.
State media reported in October that the first child she sold was her own son while in “financial difficulties” decades ago.
China classifies death penalty statistics as a state secret, though rights groups believe thousands of people are executed there every year.
A court jailed six people in 2023 for trafficking a woman found chained in a dirt-floor hut in eastern Jiangsu province.
China began allowing all families to have two children in 2016 and three children from 2021.
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